International cruise lines operating from destinations including North America, Mexico, and Europe service Grand Cayman and Cayman Brac. Mid-week is the busiest time to travel by ship.

Cayman Airways is the national airline and has service to Grand Cayman and Cayman Brac from destinations that include Miami, Tampa, and Orlando Florida; Houston, Texas; La Ceiba, Honduras; and Kingston, Jamaica. Several USA carriers offer service to Grand Cayman from cities including Miami, Tampa, Orlando, Atlanta, Houston, Indianapolis, and Pittsburgh. British Airways offers a few flights each week from London Gatwick to Grand Cayman. Air Jamaica flies to the Cayman Islands from Kingston and Montego Bay.

Miami is about an hour away by air, whereas flights from London to Grand Cayman take about 10 hours. Grand Cayman Owen Roberts International Airport and Cayman Brac Gerard Smith Airport are both international. Taxi, hotel shuttle, and car rental services are available. There is a departure tax of CI $10 or US $12.50 for all travelers over the age of 12.